What is Naltrexone (including low-dose)?
Low-dose naltrexone (LDN) is prescribed off-label for chronic pain, inflammation and autoimmune conditions; standard doses treat alcohol and opioid dependence.
At Pharmacy on the Park, Naltrexone is compounded in our pharmacy from a prescription, in the strength and form your prescriber orders.
How does it work?
At standard doses it blocks opioid receptors. At low doses it briefly blocks them, which is thought to prompt the body to make more of its own endorphins and to calm certain immune cells.
What is it used for?
Low-dose naltrexone (LDN) is prescribed off-label for chronic pain, inflammation and autoimmune conditions; standard doses treat alcohol and opioid dependence. Your prescriber determines the use, dose and monitoring.
How is it used?
- Tablet. Tablets are taken by mouth as directed on your label.
- Capsule. Capsules are swallowed by mouth. For pets, a capsule can often be hidden in a small treat if your veterinarian agrees.
- Cream. Creams are applied to the area your prescriber directs. Metered dispensers such as Topi-CLICK® deliver the same amount each time. Wash your hands after applying.
- Oral liquid. Oral liquids are shaken well and measured with the oral syringe we provide.
- Slow-release capsule. Slow-release capsules are swallowed whole. Do not open, crush or chew them.
- Gel. Gels are applied to the area directed and allowed to dry.
Follow the directions on your label. The strength, amount and schedule are set by your prescriber.
Side effects and safety
Commonly reported: Vivid dreams, trouble sleeping, headache, nausea. Blocks opioid pain relievers. Call your prescriber or us about any reaction that concerns you.
Who should use caution?
Anyone taking opioid pain medicine or who needs opioids for surgery, and people with liver disease. Share your full medical history and medication list with your prescriber.
How should it be stored?
Check your label: some liquids are refrigerated. Shake well before each dose. Always follow the storage directions and beyond-use date on your label, and keep medications out of reach of children and pets.
Why is it compounded?
Low-dose naltrexone uses strengths far below the commercial 50 mg tablet, so it is prepared by compounding.
Naltrexone is also prepared in combination with Topiramate, Bupropion. See combination preparations in our library.