784 S. Central Ave, Oviedo, FL 32765
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Compounded in OviedoBiest (estriol + estradiol) cream

Medication library / Biest (estriol + estradiol)

Hormones and HRT

Biest (estriol + estradiol)

For peopleLast updated 10/1/26
Available as
CreamRapid-dissolve tabletVaginal preparationSlow-release capsuleCapsuleTrocheOral liquidTablet
Flavors
Wild CherryRaspberry
Start with a prescriptionPrescribers: how to send it
Prescribers: download the HRT order form

Pick up in Oviedo or ship within Florida. Most compounds ready same day to 24 hours.

  • Made to your prescription. Prepared in the strength your prescriber orders.
  • 8 dosage forms. Cream, Rapid-dissolve tablet, Vaginal preparation, Slow-release capsule and more.
  • Flavor options. Wild Cherry, Raspberry.
  • Pharmacist access. Call and a person answers.
Made in our pharmacyPrescription required
What is Biest?

Combines two estrogens, estriol and estradiol, to replace estrogen after menopause.

Why is it compounded?

Biest is a combination of two estrogens in ratios your prescriber chooses, which is not available as a commercial product.

Compounded medications are prepared from a valid prescription for an individual patient and are not FDA-approved. This page is for education and is not medical advice.

Getting your prescription filled is simple

  1. Send us the prescriptionYour prescriber e-prescribes, faxes or calls it in to Pharmacy on the Park.
  2. A pharmacist reviews itWe verify it, confirm the price and timing, and call you.
  3. We compound it for youPick up in Oviedo or we ship within Florida.

What is Biest (estriol + estradiol)?

A combination of estriol and estradiol, usually 80/20 or 50/50, for menopausal hormone therapy.

At Pharmacy on the Park, Biest is compounded in our pharmacy from a prescription, in the strength and form your prescriber orders.

Compounded medications are not FDA-approved. They are prepared for one patient from a valid prescription. Any use may be off-label, and your prescriber decides whether it is right for you.

How does it work?

Combines two estrogens, estriol and estradiol, to replace estrogen after menopause.

What is it used for?

A combination of estriol and estradiol, usually 80/20 or 50/50, for menopausal hormone therapy. Your prescriber determines the use, dose and monitoring.

How is it used?

  • Cream. Creams are applied to the area your prescriber directs. Metered dispensers such as Topi-CLICK® deliver the same amount each time. Wash your hands after applying.
  • Rapid-dissolve tablet. Rapid-dissolve tablets are placed under the tongue and allowed to melt. Avoid eating or drinking until fully dissolved.
  • Vaginal preparation. Vaginal preparations are inserted with an applicator or dispenser, usually at bedtime, as directed.
  • Slow-release capsule. Slow-release capsules are swallowed whole. Do not open, crush or chew them.
  • Capsule. Capsules are swallowed by mouth. For pets, a capsule can often be hidden in a small treat if your veterinarian agrees.
  • Troche. Troches are placed between the cheek and gum and allowed to dissolve slowly. Avoid eating or drinking until fully dissolved.
  • Oral liquid. Oral liquids are shaken well and measured with the oral syringe we provide.
  • Tablet. Tablets are taken by mouth as directed on your label.

Follow the directions on your label. The strength, amount and schedule are set by your prescriber.

Side effects and safety

Commonly reported: Breast tenderness, bloating, headache, spotting. Call your prescriber or us about any reaction that concerns you.

Who should use caution?

People with a history of breast or uterine cancer, blood clots, stroke, liver disease or unexplained vaginal bleeding. Share your full medical history and medication list with your prescriber.

How should it be stored?

Store troches at room temperature unless your label says otherwise. Check your label: some liquids are refrigerated. Shake well before each dose. Always follow the storage directions and beyond-use date on your label, and keep medications out of reach of children and pets.

Why is it compounded?

Biest is a combination of two estrogens in ratios your prescriber chooses, which is not available as a commercial product.

Biest is also prepared in combination with Testosterone, Progesterone, DHEA, DMSO. See combination preparations in our library.

Personalized compounding from a pharmacy that knows your name.

“The pharmacy world needs people who are fair, and I want to be as fair to as many people as possible.”

Ian Tasman, PharmD
Owner and pharmacist, Pharmacy on the Park

IT
Quality and testing

Held to a higher standard

  • AccreditedBy The Compliance Team.
  • USP <800> compliantSafe handling of hazardous drugs.
  • Meets USP <795>Nonsterile compounding standards.
  • Meets USP <797>Every sterile batch tested by Pharmetric Labs.
Our quality standards

Our formulations

Biest is compounded to the strength your prescriber orders. These are the forms we have prepared.

FormFlavorsNotes
Cream—Creams are applied to the area your prescriber directs
Rapid-dissolve tabletWild Cherry, RaspberryRapid-dissolve tablets are placed under the tongue and allowed to melt
Vaginal preparation—Vaginal preparations are inserted with an applicator or dispenser, usually at bedtime, as directed
Slow-release capsule—Slow-release capsules are swallowed whole
Capsule—Capsules are swallowed by mouth
TrocheWild Cherry, RaspberryTroches are placed between the cheek and gum and allowed to dissolve slowly
Oral liquidWild Cherry, RaspberryOral liquids are shaken well and measured with the oral syringe we provide
Tablet—Tablets are taken by mouth as directed on your label

Forms are listed for education only. A valid prescription is required, and your prescriber chooses the form, strength and schedule. Compounded medications are not FDA-approved.

For prescribers

How to e-prescribe Biest

Compounded preparations have no NDC, so they won’t appear in a standard drug search. Use your system’s compound or free-text entry.

  1. Find Pharmacy on the Park in your pharmacy directory

    Search by NCPDP or by name and ZIP. Save us as a favorite.

    NCPDP 5747239NPI 1720664709784 S Central Ave, Oviedo, FL 32765Phone 407-977-9779Fax 407-977-0079
  2. Choose the preparation
    Biest creamBiest rapid-dissolve tabletBiest vaginal preparationBiest slow-release capsuleBiest capsuleBiest trocheBiest oral liquidBiest tablet
    Rx: Biest ___ (cream)
Quantity: ___
Sig: ___
Refills: ___
Pharmacy: Pharmacy on the Park, 784 S Central Ave, Oviedo, FL 32765 · NCPDP 5747239 · Fax 407-977-0079
  3. Enter it as a compound

    Use compound, non-formulary or free-text entry and paste the details into the prescription body. Include strength, form, directions, quantity and flavor if needed.

  4. Send it

    Transmit from your EHR, fax it to 407-977-0079, or call 407-977-9779 to speak with a pharmacist. We’ll call the patient when it’s received.

Put the formula in the prescription itself, not in “Notes to pharmacy.” Some systems don’t transmit that field.

Frequently asked questions

What is Biest?

Combines two estrogens, estriol and estradiol, to replace estrogen after menopause.

What is it used for?

A combination of estriol and estradiol, usually 80/20 or 50/50, for menopausal hormone therapy.

What forms and flavors are available?

We have prepared it as cream, rapid-dissolve tablet, vaginal preparation, slow-release capsule, capsule, troche, oral liquid, tablet. Flavors include Wild Cherry, Raspberry.

What are the common side effects?

Breast tenderness, bloating, headache, spotting.

Who should use caution?

People with a history of breast or uterine cancer, blood clots, stroke, liver disease or unexplained vaginal bleeding.

Are compounded medications FDA-approved?

No. Compounded medications are prepared for an individual patient from a prescription and are not FDA-approved.

Do I need a prescription?

Yes. Your prescriber sends the prescription to us and decides the strength and schedule.

Can you fill a prescription from my own prescriber?

Yes. Ask them to e-prescribe to Pharmacy on the Park (NCPDP 5747239), fax 407-977-0079 or call 407-977-9779.

Do you ship?

Yes, within Florida. You can also pick up at 784 S. Central Ave in Oviedo.

What is compounding?

Preparing a medication for one patient from a prescription when a commercial product isn’t the right strength, form or flavor.

Pickup and shipping

OptionWhereTiming
Pickup784 S. Central Ave, OviedoMost compounds same day to 24 hours
ShippingWithin FloridaWe confirm timing when your prescription arrives

Questions? Call 407-977-9779. A person will answer.

Explore similar medications

Related formulations

Hormones and HRT

Testosterone

Hormone replacement for men and women with low testosterone, as prescribed and monitored by a clinician.

View formulation
Hormones and HRT

Progesterone

Hormone therapy in women, often alongside estrogen, and for cycle and sleep support as prescribed.

View formulation
Hormones and HRT

Combination hormone preparations

Two or more hormones, such as estriol, estradiol, estrone, progesterone, testosterone, DHEA and pregnenolone, combined in one cream, troche, capsule or vaginal preparation, in the amounts and ratio your prescriber orders.

View formulation

References

  1. DailyMed (U.S. National Library of Medicine): drug labels for Biest
  2. PubMed: published studies on Biest
  3. MedlinePlus: patient information
  4. FDA: human drug compounding

General information about Biest as an active ingredient, pending pharmacist review. Last updated 10/1/26. Pharmacy on the Park does not decide whether a medication is right for you; your prescriber makes that call.

Call us. A person will answer.

Tell us what you need and we'll help you get it handled, whether it's a transfer, a compound or a question for your pharmacist.

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