784 S. Central Ave, Oviedo, FL 32765
Refill your prescriptions:Refill:OnlineApp StoreGoogle PlayMon–Fri 9–6 · Sat 9–noon407-977-9779Fax 407-977-0079
Pharmacy on the Park logo
Call us407-977-9779 Send a Prescription
Call us Send Prescription
Compounded in OviedoEstradiol cream

Medication library / Estradiol

Hormones and HRT

Estradiol

For peopleLast updated 10/1/26
Available as
CreamVaginal preparationGelSuppositoryCapsuleSlow-release capsuleTrocheRapid-dissolve tablet
Flavors
MarshmallowWild Cherry
Start with a prescriptionPrescribers: how to send it
Prescribers: download the HRT order form

Pick up in Oviedo or ship within Florida. Most compounds ready same day to 24 hours.

  • Made to your prescription. Prepared in the strength your prescriber orders.
  • 8 dosage forms. Cream, Vaginal preparation, Gel, Suppository and more.
  • Flavor options. Marshmallow, Wild Cherry.
  • Pharmacist access. Call and a person answers.
Made in our pharmacyPrescription required
What is Estradiol?

Replaces estradiol, the main estrogen the ovaries make before menopause.

Why is it compounded?

Compounding lets us prepare Estradiol in the exact strength your prescriber orders, in forms such as cream, vaginal preparation, gel. Flavoring helps patients take it more easily. We can also leave out dyes, fillers or allergens when needed.

Compounded medications are prepared from a valid prescription for an individual patient and are not FDA-approved. This page is for education and is not medical advice.

Getting your prescription filled is simple

  1. Send us the prescriptionYour prescriber e-prescribes, faxes or calls it in to Pharmacy on the Park.
  2. A pharmacist reviews itWe verify it, confirm the price and timing, and call you.
  3. We compound it for youPick up in Oviedo or we ship within Florida.

What is Estradiol?

Estrogen replacement for menopause symptoms such as hot flashes and vaginal dryness.

At Pharmacy on the Park, Estradiol is compounded in our pharmacy from a prescription, in the strength and form your prescriber orders.

Compounded medications are not FDA-approved. They are prepared for one patient from a valid prescription. Any use may be off-label, and your prescriber decides whether it is right for you.

How does it work?

Replaces estradiol, the main estrogen the ovaries make before menopause.

What is it used for?

Estrogen replacement for menopause symptoms such as hot flashes and vaginal dryness. Your prescriber determines the use, dose and monitoring.

How is it used?

  • Cream. Creams are applied to the area your prescriber directs. Metered dispensers such as Topi-CLICK® deliver the same amount each time. Wash your hands after applying.
  • Vaginal preparation. Vaginal preparations are inserted with an applicator or dispenser, usually at bedtime, as directed.
  • Gel. Gels are applied to the area directed and allowed to dry.
  • Suppository. Suppositories are inserted as directed. If one softens, chill it briefly before use.
  • Capsule. Capsules are swallowed by mouth. For pets, a capsule can often be hidden in a small treat if your veterinarian agrees.
  • Slow-release capsule. Slow-release capsules are swallowed whole. Do not open, crush or chew them.
  • Troche. Troches are placed between the cheek and gum and allowed to dissolve slowly. Avoid eating or drinking until fully dissolved.
  • Rapid-dissolve tablet. Rapid-dissolve tablets are placed under the tongue and allowed to melt. Avoid eating or drinking until fully dissolved.

Follow the directions on your label. The strength, amount and schedule are set by your prescriber.

Side effects and safety

Commonly reported: Breast tenderness, bloating, nausea, headache, spotting. Estrogen therapy carries boxed-warning risks your prescriber will review. Call your prescriber or us about any reaction that concerns you.

Who should use caution?

People with a history of breast or uterine cancer, blood clots, stroke, heart attack, liver disease or unexplained vaginal bleeding, and those who are pregnant. Share your full medical history and medication list with your prescriber.

How should it be stored?

Keep suppositories cool; many are refrigerated. Store troches at room temperature unless your label says otherwise. Always follow the storage directions and beyond-use date on your label, and keep medications out of reach of children and pets.

Why is it compounded?

Compounding lets us prepare Estradiol in the exact strength your prescriber orders, in forms such as cream, vaginal preparation, gel. Flavoring helps patients take it more easily. We can also leave out dyes, fillers or allergens when needed.

Estradiol is also prepared in combination with Testosterone, Estriol, Progesterone, Hyaluronic acid. See combination preparations in our library.

Personalized compounding from a pharmacy that knows your name.

“The pharmacy world needs people who are fair, and I want to be as fair to as many people as possible.”

Ian Tasman, PharmD
Owner and pharmacist, Pharmacy on the Park

IT
Quality and testing

Held to a higher standard

  • AccreditedBy The Compliance Team.
  • USP <800> compliantSafe handling of hazardous drugs.
  • Meets USP <795>Nonsterile compounding standards.
  • Meets USP <797>Every sterile batch tested by Pharmetric Labs.
Our quality standards

Our formulations

Estradiol is compounded to the strength your prescriber orders. These are the forms we have prepared.

FormFlavorsNotes
Cream—Creams are applied to the area your prescriber directs
Vaginal preparation—Vaginal preparations are inserted with an applicator or dispenser, usually at bedtime, as directed
Gel—Gels are applied to the area directed and allowed to dry
Suppository—Suppositories are inserted as directed
Capsule—Capsules are swallowed by mouth
Slow-release capsule—Slow-release capsules are swallowed whole
TrocheMarshmallow, Wild CherryTroches are placed between the cheek and gum and allowed to dissolve slowly
Rapid-dissolve tabletMarshmallow, Wild CherryRapid-dissolve tablets are placed under the tongue and allowed to melt

Forms are listed for education only. A valid prescription is required, and your prescriber chooses the form, strength and schedule. Compounded medications are not FDA-approved.

For prescribers

How to e-prescribe Estradiol

Compounded preparations have no NDC, so they won’t appear in a standard drug search. Use your system’s compound or free-text entry.

  1. Find Pharmacy on the Park in your pharmacy directory

    Search by NCPDP or by name and ZIP. Save us as a favorite.

    NCPDP 5747239NPI 1720664709784 S Central Ave, Oviedo, FL 32765Phone 407-977-9779Fax 407-977-0079
  2. Choose the preparation
    Estradiol creamEstradiol vaginal preparationEstradiol gelEstradiol suppositoryEstradiol capsuleEstradiol slow-release capsuleEstradiol trocheEstradiol rapid-dissolve tablet
    Rx: Estradiol ___ (cream)
Quantity: ___
Sig: ___
Refills: ___
Pharmacy: Pharmacy on the Park, 784 S Central Ave, Oviedo, FL 32765 · NCPDP 5747239 · Fax 407-977-0079
  3. Enter it as a compound

    Use compound, non-formulary or free-text entry and paste the details into the prescription body. Include strength, form, directions, quantity and flavor if needed.

  4. Send it

    Transmit from your EHR, fax it to 407-977-0079, or call 407-977-9779 to speak with a pharmacist. We’ll call the patient when it’s received.

Put the formula in the prescription itself, not in “Notes to pharmacy.” Some systems don’t transmit that field.

Frequently asked questions

What is Estradiol?

Replaces estradiol, the main estrogen the ovaries make before menopause.

What is it used for?

Estrogen replacement for menopause symptoms such as hot flashes and vaginal dryness.

What forms and flavors are available?

We have prepared it as cream, vaginal preparation, gel, suppository, capsule, slow-release capsule, troche, rapid-dissolve tablet. Flavors include Marshmallow, Wild Cherry.

What are the common side effects?

Breast tenderness, bloating, nausea, headache, spotting. Estrogen therapy carries boxed-warning risks your prescriber will review.

Who should use caution?

People with a history of breast or uterine cancer, blood clots, stroke, heart attack, liver disease or unexplained vaginal bleeding, and those who are pregnant.

Are compounded medications FDA-approved?

No. Compounded medications are prepared for an individual patient from a prescription and are not FDA-approved.

Do I need a prescription?

Yes. Your prescriber sends the prescription to us and decides the strength and schedule.

Can you fill a prescription from my own prescriber?

Yes. Ask them to e-prescribe to Pharmacy on the Park (NCPDP 5747239), fax 407-977-0079 or call 407-977-9779.

Do you ship?

Yes, within Florida. You can also pick up at 784 S. Central Ave in Oviedo.

What is compounding?

Preparing a medication for one patient from a prescription when a commercial product isn’t the right strength, form or flavor.

Pickup and shipping

OptionWhereTiming
Pickup784 S. Central Ave, OviedoMost compounds same day to 24 hours
ShippingWithin FloridaWe confirm timing when your prescription arrives

Questions? Call 407-977-9779. A person will answer.

Explore similar medications

Related formulations

Hormones and HRT

Testosterone

Hormone replacement for men and women with low testosterone, as prescribed and monitored by a clinician.

View formulation
Hormones and HRT

Progesterone

Hormone therapy in women, often alongside estrogen, and for cycle and sleep support as prescribed.

View formulation
Hormones and HRT

Combination hormone preparations

Two or more hormones, such as estriol, estradiol, estrone, progesterone, testosterone, DHEA and pregnenolone, combined in one cream, troche, capsule or vaginal preparation, in the amounts and ratio your prescriber orders.

View formulation

References

  1. DailyMed (U.S. National Library of Medicine): drug labels for Estradiol
  2. PubMed: published studies on Estradiol
  3. MedlinePlus: patient information
  4. FDA: human drug compounding

General information about Estradiol as an active ingredient, pending pharmacist review. Last updated 10/1/26. Pharmacy on the Park does not decide whether a medication is right for you; your prescriber makes that call.

Call us. A person will answer.

Tell us what you need and we'll help you get it handled, whether it's a transfer, a compound or a question for your pharmacist.

Call 407-977-9779Send a Prescription