784 S. Central Ave, Oviedo, FL 32765
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Compounded in OviedoHydroquinone 12% melasma cream cream

Medication library / Hydroquinone 12% melasma cream

Skin and hair

Hydroquinone 12% melasma cream

CombinationFor peopleLast updated 10/1/26
Can include
HydroquinoneTretinoinNiacinamideHydrocortisone
Available as
Cream
Start with a prescriptionPrescribers: how to send it

Pick up in Oviedo or ship within Florida. Most compounds ready same day to 24 hours.

  • Made to your prescription. Prepared in the strength your prescriber orders.
  • Custom dosage form. Cream.
  • Pharmacist access. Call and a person answers.
Made in our pharmacyPrescription required
What is Hydroquinone 12% melasma cream?

Hydroquinone blocks tyrosinase, the enzyme that makes skin pigment. Tretinoin speeds skin cell turnover and helps hydroquinone work, hydrocortisone calms irritation, and niacinamide reduces the transfer of pigment to the skin surface.

Why is it compounded?

This combination isn’t sold as a single commercial product. Compounding lets us put the ingredients together in one preparation, in the exact strengths and ratio your prescriber orders, so there are fewer separate medications to take or apply.

Compounded medications are prepared from a valid prescription for an individual patient and are not FDA-approved. This page is for education and is not medical advice.

Getting your prescription filled is simple

  1. Send us the prescriptionYour prescriber e-prescribes, faxes or calls it in to Pharmacy on the Park.
  2. A pharmacist reviews itWe verify it, confirm the price and timing, and call you.
  3. We compound it for youPick up in Oviedo or we ship within Florida.

What is Hydroquinone 12% melasma cream?

Stubborn melasma and dark spots. A high-strength cream made with hydroquinone 12%, tretinoin 0.05%, niacinamide 2% and hydrocortisone 2.5%.

At Pharmacy on the Park, Hydroquinone 12% melasma cream is compounded in our pharmacy from a prescription, in the strength and form your prescriber orders.

Compounded medications are not FDA-approved. They are prepared for one patient from a valid prescription. Any use may be off-label, and your prescriber decides whether it is right for you.

How does it work?

Hydroquinone blocks tyrosinase, the enzyme that makes skin pigment. Tretinoin speeds skin cell turnover and helps hydroquinone work, hydrocortisone calms irritation, and niacinamide reduces the transfer of pigment to the skin surface.

What is it used for?

Stubborn melasma and dark spots. A high-strength cream made with hydroquinone 12%, tretinoin 0.05%, niacinamide 2% and hydrocortisone 2.5%. Your prescriber determines the use, dose and monitoring.

How is it used?

  • Cream. Creams are applied to the area your prescriber directs. Metered dispensers such as Topi-CLICK® deliver the same amount each time. Wash your hands after applying.

Follow the directions on your label. The strength, amount and schedule are set by your prescriber.

Side effects and safety

Commonly reported: Irritation, redness, peeling and sun sensitivity. For limited-duration use with close prescriber follow-up. Call your prescriber or us about any reaction that concerns you.

Who should use caution?

Pregnancy. Long-term continuous use, which can darken or thin the skin. Use sunscreen daily. Share your full medical history and medication list with your prescriber.

How should it be stored?

Always follow the storage directions and beyond-use date on your label, and keep medications out of reach of children and pets.

Why is it compounded?

This combination isn’t sold as a single commercial product. Compounding lets us put the ingredients together in one preparation, in the exact strengths and ratio your prescriber orders, so there are fewer separate medications to take or apply.

This preparation can include: Hydroquinone, Tretinoin, Niacinamide, Hydrocortisone. Your prescriber chooses which ingredients and how much of each.

Personalized compounding from a pharmacy that knows your name.

“The pharmacy world needs people who are fair, and I want to be as fair to as many people as possible.”

Ian Tasman, PharmD
Owner and pharmacist, Pharmacy on the Park

IT
Quality and testing

Held to a higher standard

  • AccreditedBy The Compliance Team.
  • USP <800> compliantSafe handling of hazardous drugs.
  • Meets USP <795>Nonsterile compounding standards.
  • Meets USP <797>Every sterile batch tested by Pharmetric Labs.
Our quality standards

Our formulations

Hydroquinone 12% melasma cream is compounded to the strength your prescriber orders. These are the forms we have prepared.

FormFlavorsNotes
Cream—Creams are applied to the area your prescriber directs

Forms are listed for education only. A valid prescription is required, and your prescriber chooses the form, strength and schedule. Compounded medications are not FDA-approved.

For prescribers

How to e-prescribe Hydroquinone 12% melasma cream

Compounded preparations have no NDC, so they won’t appear in a standard drug search. Use your system’s compound or free-text entry.

  1. Find Pharmacy on the Park in your pharmacy directory

    Search by NCPDP or by name and ZIP. Save us as a favorite.

    NCPDP 5747239NPI 1720664709784 S Central Ave, Oviedo, FL 32765Phone 407-977-9779Fax 407-977-0079
  2. Choose the preparation
    Hydroquinone 12% melasma cream cream
    Rx: Hydroquinone 12% melasma cream ___ (cream)
Quantity: ___
Sig: ___
Refills: ___
Pharmacy: Pharmacy on the Park, 784 S Central Ave, Oviedo, FL 32765 · NCPDP 5747239 · Fax 407-977-0079
  3. Enter it as a compound

    Use compound, non-formulary or free-text entry and paste the details into the prescription body. Include strength, form, directions, quantity and flavor if needed.

  4. Send it

    Transmit from your EHR, fax it to 407-977-0079, or call 407-977-9779 to speak with a pharmacist. We’ll call the patient when it’s received.

Put the formula in the prescription itself, not in “Notes to pharmacy.” Some systems don’t transmit that field.

Frequently asked questions

What is Hydroquinone 12% melasma cream?

Hydroquinone blocks tyrosinase, the enzyme that makes skin pigment. Tretinoin speeds skin cell turnover and helps hydroquinone work, hydrocortisone calms irritation, and niacinamide reduces the transfer of pigment to the skin surface.

What is it used for?

Stubborn melasma and dark spots. A high-strength cream made with hydroquinone 12%, tretinoin 0.05%, niacinamide 2% and hydrocortisone 2.5%.

What forms and flavors are available?

We have prepared it as cream.

What are the common side effects?

Irritation, redness, peeling and sun sensitivity. For limited-duration use with close prescriber follow-up.

Who should use caution?

Pregnancy. Long-term continuous use, which can darken or thin the skin. Use sunscreen daily.

Are compounded medications FDA-approved?

No. Compounded medications are prepared for an individual patient from a prescription and are not FDA-approved.

Do I need a prescription?

Yes. Your prescriber sends the prescription to us and decides the strength and schedule.

Can you fill a prescription from my own prescriber?

Yes. Ask them to e-prescribe to Pharmacy on the Park (NCPDP 5747239), fax 407-977-0079 or call 407-977-9779.

Do you ship?

Yes, within Florida. You can also pick up at 784 S. Central Ave in Oviedo.

What is compounding?

Preparing a medication for one patient from a prescription when a commercial product isn’t the right strength, form or flavor.

Pickup and shipping

OptionWhereTiming
Pickup784 S. Central Ave, OviedoMost compounds same day to 24 hours
ShippingWithin FloridaWe confirm timing when your prescription arrives

Questions? Call 407-977-9779. A person will answer.

Explore similar medications

Related formulations

Skin and hair

Hydroquinone 5% melasma cream

Melasma and dark spots. Made with hydroquinone 5%, niacinamide 3% and vitamin C 1%.

View formulation
Skin and hair

Azelaic acid and tranexamic acid melasma cream

Melasma and dark spots, without hydroquinone. Made with azelaic acid 12%, tranexamic acid 5%, kojic acid 4% and niacinamide 3%.

View formulation
Skin and hair

Azelaic acid and kojic acid melasma cream

Melasma and dark spots, without hydroquinone. Made with azelaic acid 18%, kojic acid 4%, niacinamide 3% and vitamin C 2%.

View formulation

References

  1. DailyMed (U.S. National Library of Medicine): drug labels for Hydroquinone 12% melasma cream
  2. PubMed: published studies on Hydroquinone 12% melasma cream
  3. MedlinePlus: patient information
  4. FDA: human drug compounding

General information about Hydroquinone 12% melasma cream as an active ingredient, pending pharmacist review. Last updated 10/1/26. Pharmacy on the Park does not decide whether a medication is right for you; your prescriber makes that call.

Call us. A person will answer.

Tell us what you need and we'll help you get it handled, whether it's a transfer, a compound or a question for your pharmacist.

Call 407-977-9779Send a Prescription